反応 #2487410

反応方程式

lipoic acid

N-hydroxysuccinimide

EDC

→

(R)-Lipoamide

溶媒

CH2Cl2

ethyl acetate

反応条件

後処理

1. 1
   洗浄washed with H2O (500 mL), saturated aqueous NaHCO3 (500 mL), saturated aqueous NaCl (500 mL)
2. 2
   乾燥dried (MgSO4)
3. 3
   その他The drying agent was removed by filtration
4. 4
   濃縮the filtrate was concentrated to dryness
5. 5
   その他giving the product as

実験手順

A solution of lipoic acid (25.6 g, 124 mmol), N-hydroxysuccinimide (15.6 g, 136 mmol), and EDC (26.1 g, 136 mmol) in anhydrous CH2Cl2 (300 mL) was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate (500 mL) and washed with H2O (500 mL), saturated aqueous NaHCO3 (500 mL), saturated aqueous NaCl (500 mL) and dried (MgSO4). The drying agent was removed by filtration and the filtrate was concentrated to dryness giving the product as a yellow sold (35.4 g, 94%).

出典