反応 #2479

反応方程式

methyl 3-(N-vinylformamido)propionate

diethanolamine

sodium methoxide

→

N,N-di-(2-hydroxyethyl) 3-(N-vinylformamido)propionamide

溶媒

methanol

反応条件

後処理

1. 1
   その他A 50 mL single-neck round bottom flask equipped with a distillation head
2. 2
   その他the generated methanol was removed by distillation at reduced pressure

実験手順

A 50 mL single-neck round bottom flask equipped with a distillation head was charged with 15.1 grams (0.096 mole) of methyl 3-(N-vinylformamido)propionate, 9.95 grams (0.09 mole) of diethanolamine and 0.15 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 2 hours and the generated methanol was removed by distillation at reduced pressure. Both proton NMR and GC analyses indicated approximately a 90% conversion to the titled product.

出典