反応 #2467985

反応方程式

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

収率 65.0%

Methyl 4-aminothiophene-3-carboxylate

収率 65.0%

溶媒

water

反応条件

後処理

1. 1
   抽出The solution was extracted with chloroform
2. 2
   洗浄the combined chloroform layer was washed with water, brine
3. 3
   乾燥dried over sodium sulfate
4. 4
   ろ過The solution was filtered
5. 5
   その他evaporated the solvent

実験手順

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

出典