反応 #2467984

反応方程式

4-oxo-3-methoxycarbonyltetrahydrothiophene

hydroxylamine hydrochloride

→

title compound

収率 62.3%

Methyl 4-aminothiophene-3-carboxylate hydrochloride

収率 62.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度under reflux for 1 h
2. 2
   温度The mixture was then cooled
3. 3
   その他the solid which separated
4. 4
   ろ過was filtered off
5. 5
   洗浄washed with dry ether

実験手順

A mixture of 4-oxo-3-methoxycarbonyltetrahydrothiophene (6.5 g, 40.62 mmol), hydroxylamine hydrochloride (2.84 g, 40.62 mmol) and acetonitrile (30 mL) was stirred under reflux for 1 h. The mixture was then cooled and the solid which separated was filtered off and washed with dry ether to afford the title compound (4.9 g, 62%), mp 192-196° C.

出典