反応 #2467982

反応方程式

acrylate

Methyl acrylate

methyl thioglycolate

piperidine

acrylate

piperidine

→

product

収率 100.0%

Methyl 3-[(methoxycarbonyl)methylthio]propanoate

収率 100.0%

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄The chloroform layer was washed with water, brine
2. 2
   乾燥dried over Na2SO4
3. 3
   ろ過The solution was filtered
4. 4
   その他evaporated the solvent

実験手順

Methyl acrylate (4.25 g, 49.5 mmol) was added dropwise over 20 min to a stirred solution of methyl thioglycolate (5 g, 47.16 mmol) and piperidine (0.10 mL) at rt. When about half of the acrylate had been introduced, more piperidine (0.10 mL) was added. After completion of the addition of the acrylate, the reaction mixture was stirred for 1 h at rt. The mixture was diluted with 100 mL of chloroform. The chloroform layer was washed with water, brine and dried over Na2SO4. The solution was filtered and evaporated the solvent to give the product as an oil (9 g, 100%).

出典