反応 #2467965

反応方程式

ammonium hydroxide

Methyl 3-[(dimethylamino)diazenyl]thiophene-2-carboxylate

sulfuric acid

nitric acid

→

solid

収率 26.0%

Methyl 3-[(dimethylamino)diazenyl]-5-nitrothiophene-2-carboxylate

収率 26.0%

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was poured into ice
2. 2
   抽出The solution was extracted with chloroform (3×100 mL)
3. 3
   洗浄the combined organic layer was washed with water, brine
4. 4
   乾燥dried over sodium sulfate
5. 5
   ろ過The solution was filtered
6. 6
   その他evaporated the solvent
7. 7
   その他The residue was chromatographed over silica gel column

実験手順

Methyl 3-[(dimethylamino)diazenyl]thiophene-2-carboxylate (2 g, 9.38 mmol) was added slowly for 15 min at 0 to −5° C. to concentrated sulfuric acid (20 mL). Then concentrated nitric acid (0.54 mL, 70%, 10.7 mmol) was added to the above reaction mixture for 10 min and stirred at the same temperature for 1 h and rt for 16 h. The mixture was poured into ice cooled water and basified with ammonium hydroxide. The solution was extracted with chloroform (3×100 mL) and the combined organic layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent. The residue was chromatographed over silica gel column using hexane-ethyl acetate (80:20) as eluents to give the product as a yellow color solid (450 mg, 26%), mp 128-130° C.

出典