反応 #2467952

反応方程式

L-Ala-L-Phe

pyridine

acetic anhydride

water

→

N-[2-(acetylamino)propionyl]phenylalanine

溶媒

methylene chloride

反応条件

後処理

1. 1
   抽出the resulting mixture is extracted three times with chloroform
2. 2
   洗浄The organic layer is washed with a saturated aqueous solution of sodium chloride
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent is distilled away under reduced pressure

実験手順

L-Ala-L-Phe obtained in Experimental Example 6 (100 mg, 0.423 mmol) is suspended in methylene chloride (10 ml), and pyridine (10 ml) and acetic anhydride (1 ml, 11 mmol) are added to the suspension at room temperature. After stirring at room temperature for 24 hours, water is added and the resulting mixture is extracted three times with chloroform. The organic layer is washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and then the solvent is distilled away under reduced pressure to obtain N-[2-(acetylamino)propionyl]phenylalanine.

出典