反応 #2467951

ord-c4b343e94a0e471db7cdf61c4f6f351e

反応方程式

CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC1=O
cyclo(L-Leu-L-Phe)
CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
L-Leu-L-Phe
→
CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)O
L-Phe-L-Leu

反応物

CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC1=O
cyclo(L-Leu-L-Phe)
CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
L-Leu-L-Phe

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

As a result, it was confirmed that 6.8 mg/l cyclo(L-Leu-L-Phe), 28.7 mg/l L-Leu-L-Phe and 18.5 mg/l L-Phe-L-Leu were formed. No cyclopeptide or straight-chain peptide was detected in the reaction mixture without ATP incubated in the same manner.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08257943B2uspto-grants-2012_09