反応 #2467946

反応方程式

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid

NMM

→

desired product

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionamide

溶媒

DME

反応条件

後処理

1. 1
   濃縮Then, a solution of NH4OH concentrated
2. 2
   workup.ADDITIONwas added
3. 3
   workup.ADDITION5 mL of water was added
4. 4
   ろ過the precipitate was filtered
5. 5
   洗浄washed with H2O and hexane

実験手順

To a solution of 3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid (4b) (1.0 mmol, 337 mg) in DME (5 mL) at −15° C., were added NMM (1.1 mmol, 121 μL), then IBCF (1.1 mmol, 147 μL). Then, a solution of NH4OH concentrated was added and the mixture was stirred for 20 minutes. 5 mL of water was added and the precipitate was filtered and washed with H2O and hexane to give the desired product.

出典