反応 #2467944

反応方程式

2-Benzyl-malonic acid monoethyl ester

1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride

4-phenyl-thiazol-2-ylamine

→

2-Benzyl-N-(4-phenyl-thiazol-2-yl)-malonamic acid ethyl ester

溶媒

DMF

反応条件

後処理

1. 1
   濃縮concentrated in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in CH2Cl2 (20 mL)
3. 3
   洗浄was washed with 5% NaHCO3
4. 4
   乾燥dried with MgSO4
5. 5
   濃縮concentrated in vacuo
6. 6
   その他The residue was purified by HPLC
7. 7
   その他The product was obtained 170 mg (67%) as white solid

実験手順

To a suspension of 2-Benzyl-malonic acid monoethyl ester (150 mg, 0.67 mmol) and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (0.74 mmol) in DMF (4 mL) at 25° C. was added 4-phenyl-thiazol-2-ylamine (119 mg, 0.67 mmol), the resulting mixture was stirring at 25° C. for overnight and concentrated in vacuo, and the residue was dissolved in CH2Cl2 (20 mL) was washed with 5% NaHCO3, dried with MgSO4 and concentrated in vacuo. The residue was purified by HPLC. The product was obtained 170 mg (67%) as white solid.

出典