反応 #2467943

反応方程式

2-benzylmalonic acid diethyl ester

KOH

→

final product

2-Benzyl-malonic acid monoethyl ester

溶媒

EtOH

EtOH

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting liquid dissolved in 5% NaHCO3 (30 mL)
3. 3
   洗浄washed with EtOAc (3×10 mL)
4. 4
   抽出back extracted with 5% NaHCO3 (50 mL)
5. 5
   抽出extracted with EtOAc
6. 6
   洗浄The organic layer was washed with H2O
7. 7
   乾燥dried with Na2SO4
8. 8
   その他The solvent was removed under reduced pressure

実験手順

To a solution of 2-benzylmalonic acid diethyl ester 2.5 g (10 mmol) in EtOH (10 mL) was added 1N KOH in EtOH (8.5 mL). The solution was stirred for 1 h at room temperature. The solvent was removed under reduced pressure, and the resulting liquid dissolved in 5% NaHCO3 (30 mL), washed with EtOAc (3×10 mL), and back extracted with 5% NaHCO3 (50 mL). The combined NaHCO3 solutions were acidified to pH=3 with 1N HCl and extracted with EtOAc. The organic layer was washed with H2O, dried with Na2SO4. The solvent was removed under reduced pressure to give final product as oil, 1.4 g (74%).

出典