反応 #2467942

反応方程式

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester

KOH

→

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid

収率 83.7%

溶媒

ethanol

反応条件

後処理

1. 1
   その他After the solvent was evaporated from the reaction mixture
2. 2
   workup.DISSOLUTIONthe residue was dissolved
3. 3
   workup.ADDITIONby adding water
4. 4
   その他The produced precipitates
5. 5
   ろ過were filtered with suction
6. 6
   洗浄washed with water

実験手順

To a solution of 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester (74 mg, 0.2 mmol) dissolved in ethanol (4 mL) was added 1N—KOH (0.5 mL, 0.5 mmol) and the mixture was stirred at room temperature for 2 hours. After the solvent was evaporated from the reaction mixture, the residue was dissolved by adding water and acidified (H=2) with 2N—HCl under ice cooling. The produced precipitates were filtered with suction, washed with water to afford 59 mg (yield 80%) of the desired 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid as white solids.

出典