反応 #2467936

反応方程式

thiosemicarbazide

3,4-dichlorophenylacetyl bromide

→

4-(3,4-Dichloro-phenyl)-thiazol-2-yl-hydrazine

溶媒

dioxane

反応条件

後処理

1. 1
   ろ過The precipitate of hydrobromide salt was filtered
2. 2
   洗浄washed with dioxane (3×10 mL)
3. 3
   ろ過The product was filtered
4. 4
   洗浄washed with water
5. 5
   その他dried (2.08 g, 80%)
6. 6
   その他The product was generally satisfactory for further reaction

実験手順

A solution of a thiosemicarbazide (10 mmol, 0.91 g) and 3,4-dichlorophenylacetyl bromide (10 mmol, 2.68 g) in dioxane (20 mL) was stirred at room temperature for 16 h. The precipitate of hydrobromide salt was filtered and washed with dioxane (3×10 mL), then basified with 2N Na2CO3 (20 mL). The product was filtered, washed with water and dried (2.08 g, 80%). The product was generally satisfactory for further reaction.

出典