反応 #2467911

反応方程式

z,z,z-octadeca-6,9,12-trienoic acid

1,3-dihydroxypropane

1,3-dicyclohexylcarbodiimide

→

1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   ろ過was filtered
2. 2
   洗浄The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution
3. 3
   その他The solution was dried
4. 4
   濃縮concentrated
5. 5
   その他purified
6. 6
   その他by dry column chromatography

実験手順

A solution of z,z,z-octadeca-6,9,12-trienoic acid (150 g) in methylene chloride (500 ml) was added dropwise to a mixture of 1,3-dihydroxypropane (205 g), 1,3-dicyclohexylcarbodiimide (130 g) and 4-(N,N-dimethylamino)pyridine (87 g) in methylene chloride (2500 ml) at room temperature under nitrogen. When tlc indicated that the reaction had gone to completion the reaction mixture was filtered. The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution. The solution was dried, concentrated and purified by dry column chromatography to yield 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane as a pale yellow oil.

出典