反応 #2467009

反応方程式

2-amino-4-bromoacetylthiazole hydrobromide

N-[(thiocarbamoyl)methyl]-acetamide

→

4-(2-acetylaminomethylthiazol-4-yl)-2-aminothiazole

収率 49.7%

溶媒

ethanol

反応条件

後処理

1. 1
   その他The insoluble material was removed by filtration
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   抽出was extracted with a mixture of ethyl acetate (500 ml) and tetrahydrofuran (100 ml)
4. 4
   乾燥The extract was dried over magnesium sulfate
5. 5
   その他was evaporated

実験手順

A suspension of 2-amino-4-bromoacetylthiazole hydrobromide (14.0 g) and N-[(thiocarbamoyl)methyl]-acetamide (6.1 g) in ethanol (300 ml) was stirred at room temperature for 24 hours. The insoluble material was removed by filtration. The solvent was removed under reduced pressure. The residue was suspended in water (300 ml). The mixture was alkalized to pH 10 with a saturated aqueous potassium carbonate solution and then was extracted with a mixture of ethyl acetate (500 ml) and tetrahydrofuran (100 ml). The extract was dried over magnesium sulfate and then was evaporated to afford 4-(2-acetylaminomethylthiazol-4-yl)-2-aminothiazole (5.83 g).

出典