反応 #2460338

ord-42eb0222d0924b0c86fd851cbf3ed77e

反応方程式

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid
→
CCS(=O)(=O)[O-].Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
Olanzapine Esylate

反応物

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid

試薬

なし

溶媒

CC(C)=O
acetone
CC(C)=O
acetone

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他to form
  2. 2
    その他the crystals were isolated by filtration
  3. 3
    洗浄washed with 50 ml acetone

実験手順

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added 1.76 g ethane sulfonic acid in 50 ml acetone at room temperature. Immediately a solid started to form. After stirring for 3 hours, the crystals were isolated by filtration and washed with 50 ml acetone. Yield: 6.59 g (97%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07459449B2uspto-grants-2008_12