反応 #2460335

反応方程式

olanzapine

glycolic acid

olanzapine

→

Olanzapine Glycolate

溶媒

acetone

acetone

反応条件

後処理

1. 1
   その他The formed crystals were isolated by filtration
2. 2
   その他dried overnight at 40° C. in vacuo
3. 3
   その他Isolated yield: 84.1 gram (90%)

実験手順

To a clear solution of 75 g olanzapine free base in 1500 ml acetone, was added slowly 18.0 g glycolic acid in 100 ml acetone at room temperature. The resulting mixture was stirred at room temperature overnight. The formed crystals were isolated by filtration and dried overnight at 40° C. in vacuo. Isolated yield: 84.1 gram (90%). 1H-NMR confirms the molar ratio olanzapine:acid=1:1.

出典