反応 #2460331

反応方程式

benzoic acid

olanzapine

olanzapine

→

Olanzapine Benzoate

溶媒

ethyl acetate

ethyl acetate

反応条件

後処理

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   その他The crystals were isolated by filtration
3. 3
   その他dried overnight at 50° C. in vacuo
4. 4
   その他Isolated yield: 0.64 gram (92%)

実験手順

To a clear solution of 0.196 g benzoic acid in 5 ml ethyl acetate was added slowly a clear hot solution of 0.5 g olanzapine free base in 10 ml ethyl acetate. After complete addition, slowly, the crystallization process started. Stirring at room temperature was continued for 5 hours. The crystals were isolated by filtration and dried overnight at 50° C. in vacuo. Isolated yield: 0.64 gram (92%). 1H-NMR confirmed the molar ratio olanzapine: acid=1:1.

出典