反応 #2460330

反応方程式

olanzapine

benzoic acid

→

Olanzapine Benzoate

溶媒

acetone

acetone

反応条件

後処理

1. 1
   その他the crystals were isolated by filtration
2. 2
   洗浄washed with acetone (20 ml)
3. 3
   その他dried overnight at 40° C

実験手順

To a clear solution of olanzapine free base (5.0 g) in acetone (150 ml) was added slowly a solution of 1.0 equivalent of benzoic acid (1.96 g) in acetone (20 ml) at room temperature. After stirring at 4° C. overnight, the crystals were isolated by filtration, washed with acetone (20 ml) and dried overnight at 40° C. Yield: 6.23 g (90%).

出典