反応 #2460310

反応方程式

butyl 4′-(trifluoromethyl)biphenyl-4-carboxylate

butyl 3-iodobenzoate

→

butyl 4′-(trifluoromethyl)biphenyl-3-carboxylate

収率 40.0%

反応条件

後処理

1. 1
   その他The product was purified by column chromatography
2. 2
   workup.DISTILLATIONfollowed by vacuum distillation
3. 3
   その他collecting fraction bp 127-131° C./0.12 mm
4. 4
   その他obtained in 40% yield

実験手順

This compound was prepared by the procedure for butyl 4′-(trifluoromethyl)biphenyl-4-carboxylate (CS-16), except using butyl 3-iodobenzoate instead of butyl 4-iodobenzoate. The product was purified by column chromatography followed by vacuum distillation, collecting fraction bp 127-131° C./0.12 mm. The product was a colorless oil, and obtained in 40% yield. 1H NMR (CDCl3): δ 0.99 (t, 3H), 1.5 (m, 2H), 1.8 (m, 2H), 4.37 (t, 2H), 7.54 (d, 2H), 7.72 (s, 4H), 7.77 (d, 2H), 8.09 (d, 2H), 8.28 (s, 2H).

出典