反応 #2460297

反応方程式

2-(2-methoxyphenylthio)benzoic acid

acetic anhydride

sulfuric acid

→

2-methoxythioxanthen-9-one

反応条件

後処理

1. 1
   温度cooled
2. 2
   抽出The precipitate was extracted with dichloromethane
3. 3
   洗浄the extract was washed with 10% aqueous NaHCO3
4. 4
   乾燥The solution was dried (MgSO4)
5. 5
   濃縮concentrated
6. 6
   その他The product was purified by successive recrystallizations from isopropanol and from toluene/heptane

実験手順

Finally, 2-methoxythioxanthen-9-one (S-17) was prepared. To a mixture of 2-(2-methoxyphenylthio)benzoic acid (11.0 g, 42 mmol) and 43.1 g (423 mmol) of acetic anhydride was added dropwise 4.14 g (42 mmol) of concentrated sulfuric acid. The mixture was heated at 80° C. for 4 h, cooled to ambient, and poured very slowly onto 500 g of ice. The precipitate was extracted with dichloromethane, and the extract was washed with 10% aqueous NaHCO3 and then with brine. The solution was dried (MgSO4), passed through a short column of silica gel, and concentrated to deposit an orange solid. The product was purified by successive recrystallizations from isopropanol and from toluene/heptane. 1H NMR (CDCl3): δ 3.95 (s, 3H), 7.27 (dd, 1H), 7.5 (m, 2H), 7.6 (m, 2H), 8.09 (d, 1H), 8.64 (d 1H).

出典