反応 #2460284

反応方程式

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

溶媒

water

acetone

ethyl acetate

反応条件

後処理

1. 1
   温度The reaction was refluxed under nitrogen
2. 2
   温度After 5-6 hours of reflux
3. 3
   その他the organic layer was separated
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他evaporated to dryness
6. 6
   その他to afford a white fluffy powder

実験手順

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5-6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

出典