反応 #2452

反応方程式

p-bromo anisole

acrylic acid

triethyamine

→

p-methoxy cinnamic acid

収率 81.2%

溶媒

water

water

反応条件

後処理

1. 1
   その他recovered by phase separation from a previous run)
2. 2
   workup.ADDITIONwere charged into an autoclave

実験手順

p-bromo anisole (8.4 g), acrylic acid (3.9 g), water (13.5 g), PdCl2 (0.3 mg) and triethyamine (14.3 g, 89.3% pure by titration, the balance being water, recovered by phase separation from a previous run) were charged into an autoclave and heated for 2 hours at 130° C. The work up detailed in Example 1 gave 6.5 g (81%) of >98% pure p-methoxy cinnamic acid.

出典