反応 #2449

反応方程式

9-formyl-7, 12-dioxaspiro[5,6]dodecane

NaBH4

→

9-hydroxymethyl-7, 12-dioxaspiro[5,6]dodecane

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONAfter complete addition
2. 2
   workup.STIRRINGthe reaction mixture was stirred for 3 hr at 20° C
3. 3
   その他The product residue obtained
4. 4
   その他after evaporation of methanol
5. 5
   workup.ADDITIONwas treated with water (20 ml)
6. 6
   抽出extracted into ether
7. 7
   乾燥dried over K2CO3
8. 8
   その他Evaporation of ether

実験手順

To a solution of 9-formyl-7, 12-dioxaspiro[5,6]dodecane of formula IV (5 g) in methanol (15 ml) was added in small portions NaBH4 (0.5 g) while stirring the solution and maintaining the temperature at 10° C. After complete addition, the reaction mixture was stirred for 3 hr at 20° C. The product residue obtained after evaporation of methanol was treated with water (20 ml), extracted into ether and dried over K2CO3. Evaporation of ether gave 9-hydroxymethyl-7, 12-dioxaspiro[5,6]dodecane of formula V (5 g) of the drawings as colorless viscous liquid.

出典