反応 #2446118

ord-0251c1bd47a54ef6a8605051d3eb716c

反応方程式

N=C(N)NCCC[C@H](N)C(=O)O
L-arginine
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
tazobactam acid
→
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O.N=C(N)NCCC[C@H](N)C(=O)O
tazobactam arginine
収率 101.3%

反応物

N=C(N)NCCC[C@H](N)C(=O)O
L-arginine
C[C@]1(Cn2ccnn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
tazobactam acid

試薬

なし

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他resulting a homogenous solution

実験手順

L-arginine (2.9 g) was dissolved in 100 mL of deionized water and 5.0 g of tazobactam acid was then added, resulting a homogenous solution. The solution was lyophilized overnight to yield tazobactam arginine amorphous as an off-white solid (8.0 g). The XRPD spectrum of the tazobactam arginine amorphous is depicted in FIG. 5.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08685957B1uspto-grants-2014_04