反応 #2446097

反応方程式

water

Dibenzofuran-2-carboxaldehyde

Butyl lithium

→

2-Vinyl-dibenzofuran

収率 95.0%

溶媒

THF

THF

Hexane

反応条件

後処理

1. 1
   その他equipped with a magnetic stirrer
2. 2
   その他the internal temperature below 3° C
3. 3
   workup.ADDITIONare added within 30 minutes
4. 4
   温度After two hours the reaction mixture is warmed to room temperature
5. 5
   抽出extracted three times with 500 ml of Ethylacetate
6. 6
   洗浄The combined organic phases are washed once with 500 ml of a 1:1 mixture of buffer pH=1 and brine, once with 30 ml of brine
7. 7
   乾燥dried over Magnesiumsulfate
8. 8
   ろ過filtered
9. 9
   その他evaporated
10. 10
    workup.DISSOLUTIONThe crude product is dissolved in Dichloromethane
11. 11
    workup.ADDITION100 g of silica are added
12. 12
    その他the solvent is evaporated
13. 13
    workup.ADDITIONThe resulting powder is added on top of 300 g of silica in a sintered glass funnel
14. 14
    洗浄the product eluted with Hexane/Ethylacetate=8:1
15. 15
    その他The product is crystallized from 2-Propanol

実験手順

22.7 g (63.7 mmol) of Methyl triphenylphosphonium bromide and 200 ml of dry THF are placed in a dried 500 ml three necked round bottomed flask, equipped with a magnetic stirrer and the reaction mixture is cooled to 0° C. internal temperature with a NaCl/ice bath. 41.8 ml (66.9 mmol) of 1.6 M Butyl lithium solution in Hexane are added within 30 minutes while keeping the internal temperature below 3° C. The reaction mixture is stirred at the same temperature for 45 minutes, then 47.2 mmol of Dibenzofuran-2-carboxaldehyde dissolved in 100 ml of dry THF are added within 30 minutes. After two hours the reaction mixture is warmed to room temperature, added to 500 ml of water and extracted three times with 500 ml of Ethylacetate. The combined organic phases are washed once with 500 ml of a 1:1 mixture of buffer pH=1 and brine, once with 30 ml of brine, dried over Magnesiumsulfate, filtered and evaporated. The crude product is dissolved in Dichloromethane, 100 g of silica are added and the solvent is evaporated. The resulting powder is added on top of 300 g of silica in a sintered glass funnel and the product eluted with Hexane/Ethylacetate=8:1. The product is crystallized from 2-Propanol. 2-Vinyl-dibenzofuran is isolated in 95% yield.

出典