反応 #2439971

反応方程式

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

3-aminophenol

→

title compound

収率 20.0%

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (4-{3-[(3-hydroxy-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carbonyl}-phenyl)-amide

収率 20.0%

溶媒

THF

反応条件

後処理

1. 1
   その他A small screw cap test tube
2. 2
   温度Subsequently, the reaction mixture was cooled to room temperature
3. 3
   その他The solid precipitate that formed

実験手順

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (as prepared in Example 15, 100 mg, 0.240 mmol) and THF (2 mL). To the resulting solution was added 3-aminophenol (28.8 mg, 0.264 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 20% (24 mg, 0.047 mmol) of the title compound.

出典