反応 #2439961

反応方程式

5-(4-Nitro-benzyl)-1,3-dihydro-indol-2-one

→

5-(4-Amino-benzyl)-1,3-dihydro-indol-2-one

収率 58.0%

溶媒

MeOH

反応条件

後処理

1. 1
   その他The flask was evacuated
2. 2
   workup.ADDITIONthen charged with H2(g) (55 psi)
3. 3
   その他to degas the reaction mixture)
4. 4
   workup.ADDITIONThe reaction vessel charged with H2(g) (55 psi)
5. 5
   ろ過were filtered through celite
6. 6
   濃縮The organic solution was then concentrated in vacuo

実験手順

5-(4-Nitro-benzyl)-1,3-dihydro-indol-2-one (0.524 g, 1.94 mmols) was suspended in 35 ml of MeOH. 5% Pd/C (50 mg) was added to the flask which then was placed on a PARR apparatus. The flask was evacuated then charged with H2(g) (55 psi). This evacuation/H2(g) fill procedure was repeated 3 times (to degas the reaction mixture). The reaction vessel charged with H2(g) (55 psi) was shaken on the PARR apparatus for 2.5 hours after which the contents were filtered through celite. The organic solution was then concentrated in vacuo affording 5-(4-Amino-benzyl)-1,3-dihydro-indol-2-one at 58% yield (0.267 g, 1.12 mmol).

出典