反応 #2439947

反応方程式

AlCl3

oxindole

HCl

4-nitrobenzoyl chloride

→

5-(4-Nitro-benzoyl)-1,3-dihydro-indol-2-one

収率 96.0%

溶媒

water

DMF

DMF

DMF

反応条件

後処理

1. 1
   workup.ADDITIONoutside as this addition
2. 2
   その他formed
3. 3
   温度The mixture was warmed to 50° C.
4. 4
   workup.STIRRINGstirred for 15 min at that temperature
5. 5
   その他The resulting reaction mixture
6. 6
   温度was heated to 90° C.
7. 7
   workup.STIRRINGto stir for 5 hours during which the reaction mixture
8. 8
   温度The reaction was cooled to room temperature
9. 9
   workup.ADDITIONIce was added directly to the flask
10. 10
    workup.STIRRINGthe contents were stirred at room temperature for 15 min
11. 11
    ろ過The precipitate was collected via vacuum filtration
12. 12
    その他The crude solid was purified
13. 13
    洗浄by washing with sat. NaHCO3(aq)

実験手順

AlCl3 (20.0 g, 150 mmol) was placed in a dry 200 mL round bottom flask and DMF (3.30 mL) was added dropwise at 0° C. During the addition of DMF care was taken to ensure that the reaction was allowed to vent to the outside as this addition caused an exotherm to occur. Additionally as the DMF was added a white suspension formed. This suspension was allowed to stir for 30 min at room temperature, after which 4-nitrobenzoyl chloride (2.984 g, 16 mmol) was added. The mixture was warmed to 50° C. and stirred for 15 min at that temperature. The 50° C. mixture then was treated with oxindole (2.051 g, 15 mmol). The resulting reaction mixture was heated to 90° C. and allowed to stir for 5 hours during which the reaction mixture turned from a yellowish suspension to a thick black oil. The reaction was cooled to room temperature. Ice was added directly to the flask followed by water, turning the black oil into a pale yellow/white precipitate. Concentrated HCl(aq) (3 mL) was added to the reaction and the contents were stirred at room temperature for 15 min. The precipitate was collected via vacuum filtration. The crude solid was purified by washing with sat. NaHCO3(aq) providing 5-(4-Nitro-benzoyl)-1,3-dihydro-indol-2-one as a gray solid (4.05 g, 14.4 mmol, 95%).

出典