反応 #2439942

反応方程式

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

THF

5-amino-2-methoxyphenol

→

title compound

収率 67.0%

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (3-{3-[(3-hydroxy-4-methyl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-5-carbonyl}-phenyl)-amide

収率 67.0%

溶媒

反応条件

後処理

1. 1
   その他A small screw cap test tube
2. 2
   温度Subsequently, the reaction mixture was cooled to room temperature
3. 3
   その他The solid precipitate that formed

実験手順

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (as prepared in Example 1, 30 mg, 0.072 mmol) and THF (1 mL). To the resulting solution was added 5-amino-2-methoxyphenol (13.3 mg, 0.1082 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 67% (25 g, 0.048 mmol) of the title compound.

出典