反応 #2439923

反応方程式

2-phenyl-6-(acetoxymethyl)-pyridine

→

2-phenyl-6-(hydroxymethyl)-pyridine

収率 81.0%

溶媒

HCl

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度at reflux temperature
3. 3
   濃縮After 30 minutes the reaction mixture was concentrated with the aid of an oil pump (10 mm) at 40° C.
4. 4
   workup.ADDITIONCH3CN was added
5. 5
   その他the mixture was evaporated to dryness in vacuo

実験手順

4.5 g of 2-phenyl-6-(acetoxymethyl)-pyridine (20 mmol) was treated with an aqueous HCl solution (15%, 10 ml) and the mixture was heated at reflux temperature while stirring. After 30 minutes the reaction mixture was concentrated with the aid of an oil pump (10 mm) at 40° C., CH3CN was added, and the mixture was evaporated to dryness in vacuo and yielded 2-phenyl-6-(hydroxymethyl)-pyridine (3.0 g, 80%) as an oil.

出典