反応 #2439847

反応方程式

methyl 2-butynoate

1-Octanethiol

→

methyl (E)-3-octylthio-2butenoate

溶媒

ether

反応条件

後処理

1. 1
   温度with cooling with an ice bath
2. 2
   その他to come to RT
3. 3
   洗浄washed
4. 4
   その他dried
5. 5
   その他the product is purified by prep

実験手順

Two drops of DBU is added to methyl 2-butynoate (6.0 g) under N2. 1-Octanethiol (8.96 g, 61.2 mmol) is added dropwise over 20 min. with cooling with an ice bath. The mixture is allowed to come to RT and is stirred overnight. It is then diluted with ether, washed, dried and stripped and the product is purified by prep. TLC to give methyl (E)-3-octylthio-2butenoate.

出典