反応 #2426

反応方程式

13D

5-(2-nitrobenzoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-pyrazole

→

mixture

収率 49.0%

5-(2-Aminobenzoyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-pyrazole

収率 49.0%

溶媒

THF

反応条件

後処理

1. 1
   その他degassed
2. 2
   workup.ADDITION-on-carbon (1.2 g) was added
3. 3
   ろ過The mixture was filtered
4. 4
   ろ過(celite filter aid)
5. 5
   その他evaporated
6. 6
   その他chromatographed (eluant 30% EtOAc in hexanes)

実験手順

The mixture of pyrazoles of examples 13C and 13D (2.35 g, 6.772 mmol) was taken up in dry THF (100 ml) and degassed. 5% Pd.-on-carbon (1.2 g) was added and the mixture hydrogenated at 30 psi and ambient temperature for 2 h. The mixture was filtered (celite filter aid) and evaporated and then chromatographed (eluant 30% EtOAc in hexanes) to provide the two tide compounds as an equimolar mixture (1.05 g, 49%).

出典