反応 #2410

反応方程式

2-(6-aminopyrimidin-4-yloxy)ethanol

bromine

→

2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol

収率 104.7%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   その他The mixture is evaporated
2. 2
   その他to remove the solvent
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   workup.ADDITIONThe mixture is treated with saturated aqueous sodium hydrogen carbonate solution
5. 5
   抽出extracted with ethyl acetate/tetrahydrofuran
6. 6
   洗浄The organic layer is washed
7. 7
   その他dried
8. 8
   その他evaporated
9. 9
   その他to remove the solvent

実験手順

To a suspension of 2-(6-aminopyrimidin-4-yloxy)ethanol (400 mg) in methanol (4 ml) is added dropwise a solution of bromine (437 mg) in methanol (2 ml). The mixture is evaporated to remove the solvent, and the residue is dissolved in ethyl acetate. The mixture is treated with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate/tetrahydrofuran. The organic layer is washed, dried, and evaporated to remove the solvent to give 2-(6-amino-5-bromopyrimidin-4-yloxy)ethanol (632 mg).

出典