反応 #2407
ord-f570953042144533ac7122491f64e455
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度cooling
- 2その他evaporated
- 3その他to remove the solvent
- 4抽出The residue is extracted with ethyl acetate
- 5抽出the ethyl acetate extract
- 6その他is dried
- 7濃縮concentrated under reduced pressure
- 8その他The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)
実験手順
To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.