反応 #2404

反応方程式

4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide

sodium hydride

ethylene glycol

hydrochloric acid

→

4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide

反応条件

後処理

1. 1
   温度After cooling
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The ethyl acetate layer is washed
4. 4
   その他dried
5. 5
   その他evaporated
6. 6
   その他to remove the solvent
7. 7
   その他The residue is crystallized from ethyl acetate

実験手順

To ethylene glycol (20 ml) is added sodium hydride (60% dispersion-type, 1.03 g), and thereto is added 4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide (1.66 g). The mixture is stirred at 60° C. for 20 hours. After cooling, the mixture is acidified with 10% hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from ethyl acetate to give 4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide (1.58 g).

出典