反応 #2398

反応方程式

2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

sodium azide

dimethyformamide

→

2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol

収率 87.5%

溶媒

water

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度After cooling
3. 3
   抽出extracted with ethyl acetate
4. 4
   洗浄The ethyl acetate layer is washed
5. 5
   その他dried
6. 6
   その他evaporated
7. 7
   その他to remove the solvent
8. 8
   その他The residue is crystallized from hexane

実験手順

A mixture of 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (21.85 g), sodium azide (10.7 g) and dimethyformamide (260 ml) is heated with stirring at 75°-80° C. overnight. After cooling, the mixture is treated with water, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane to give 2-{6-azido-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (19.6 g).

出典