反応 #2396535

反応方程式

trimethylaluminum

2-(1-methyl-1H-pyrazol-4-yl)benzenesulfonamide

methyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

→

title compound

収率 17.6%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(1-methyl-1H-pyrazol-4-yl)benzenesulfonamide

収率 17.6%

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他After work up and evaporation of the methylene chloride solvent
2. 2
   その他the residue was triturated with ethyl acetate

実験手順

By the procedure of Example 14, 2 g of 2-(1-methyl-1H-pyrazol-4-yl)benzenesulfonamide, prepared in Example 19, was reacted in 100 ml of methylene chloride with 0.7 g of trimethylaluminum (5 ml of 2M toluene solution) followed by 1.7 g of methyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate. After work up and evaporation of the methylene chloride solvent, the residue was triturated with ethyl acetate to yield 0.6 g of the title compound; m.p. 221°-224° C. The IR spectrum showed a carbonyl absorption at 1700 cm-1 indicative for a sulfonylurea.

出典