反応 #2389078

反応方程式

4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one

hydrogen

sodium acetate

sodium acetate hydrate

→

product

収率 52.6%

4-(6-Methoxy-2-naphthyl)butan-2-one

収率 52.6%

溶媒

methanol

water

water

反応条件

後処理

1. 1
   洗浄The hydrogenator is washed with nitrogen in order
2. 2
   workup.ADDITIONhydrogen is introduced at the pressure of 2 atmospheres
3. 3
   その他The temperature of reaction
4. 4
   洗浄the hydrogenator is washed with nitrogen
5. 5
   ろ過the reaction mixture is filtered
6. 6
   濃縮concentrated under vacuum
7. 7
   workup.DISSOLUTIONThe oily residue is dissolved into 130 ml of isopropanol and 30 ml of N,N-dimethylformamide
8. 8
   workup.ADDITIONthe solution is added with 45 ml of water and 17.6 g of sodium bisulfite obtaining a suspension that
9. 9
   温度is cooled to 5° C.
10. 10
    ろ過is filtered
11. 11
    洗浄The obtained solid is washed with 75 ml of methanol
12. 12
    workup.STIRRINGunder stirring at room temperature for three hours
13. 13
    ろ過The suspension is then filtered
14. 14
    洗浄the solid is washed with water until neutrality
15. 15
    その他dried in oven under vacuum

実験手順

48 Grams (0.150 moles) of 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one, 6.1 g of sodium acetate hydrate containing 32.4% of water, equivalent to 0.050 moles of sodium acetate, 4 g of a 50% suspension in water of 10% palladium on carbon, equivalent to 0.0019 moles of palladium, and 500 ml of methanol are put in a hydrogenator. The hydrogenator is washed with nitrogen in order to eliminate the oxygen and then hydrogen is introduced at the pressure of 2 atmospheres. The temperature of reaction is kept at 40° C. for a period of time of 6 hours, then the hydrogen is let off, the hydrogenator is washed with nitrogen and the reaction mixture is filtered to eliminate the catalyst. The solution is brought to pH 6 with a 5% aqueous solution of sodium hydroxide and concentrated under vacuum. The oily residue is dissolved into 130 ml of isopropanol and 30 ml of N,N-dimethylformamide and the solution is added with 45 ml of water and 17.6 g of sodium bisulfite obtaining a suspension that is stirred for one hour at 60° C., then is cooled to 5° C. and is filtered. The obtained solid is washed with 75 ml of methanol, suspended in 200 ml of a 5% aqueous solution of sodium hydroxide and kept under stirring at room temperature for three hours. The suspension is then filtered, the solid is washed with water until neutrality and dried in oven under vacuum obtaining 18 g of product with a yield equal to 52.8%.

出典