反応 #2383815

反応方程式

EtOAc

cyclohexanone

potassium t-butoxide

3-butenyl bromide

→

2-(3-butenyl) cyclohexanone

溶媒

toluene

反応条件

後処理

1. 1
   温度The reaction is warmed to room temperature
2. 2
   洗浄washed once with 10% potassium hydrogen sulfate
3. 3
   洗浄The organic solution is then washed with brine
4. 4
   乾燥dried over magnesium sulfate
5. 5
   その他the solvent evaporated under reduced pressure

実験手順

A suspension of potassium t-butoxide in toluene cooled to 0° C. in an ice bath under N2 is treated with cyclohexanone. To the reaction mixture is slowly added 3-butenyl bromide. The reaction is warmed to room temperature. The reaction is then poured into EtOAc and washed once with 10% potassium hydrogen sulfate. The organic solution is then washed with brine, dried over magnesium sulfate, and the solvent evaporated under reduced pressure to afford 2-(3-butenyl) cyclohexanone.

出典