反応 #2383813

反応方程式

product

6,7,8,9-tetrahydro-5-(3-hydroxypropyl)-3H,5H-[1,2,4]oxadiazolo[4,3-a]azepin-3-one

carbon tetrabromide

triphenylphosphine

→

title compound

5-(3-bromopropyl)-6,7,8,9-tetrahydro-3H,5H-[1,2,4]oxadiazolo[4,3-a]azepin-3-one

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他the solvent is removed under reduced pressure
2. 2
   workup.DISSOLUTIONThe crude product is dissolved in an eluting solvent system
3. 3
   その他chromatographed

実験手順

To a solution of the product of Example 11 in methylene chloride at 0° C. is added carbon tetrabromide and triphenylphosphine. The reaction is stirred for 2 hours and the solvent is removed under reduced pressure. The crude product is dissolved in an eluting solvent system and chromatographed to afford the title compound.

出典