反応 #2383805

反応方程式

hydrazine hydrate

hydrazine hydrate

5-nitro-2,3-dihydrophthalazine-1,4-dione

water

5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt

→

5-amino-2,3-dihydrophthalazine-1,4-dione

hydrazine hydrate

溶媒

acetic acid

反応条件

後処理

1. 1
   その他at 90-120° C.

実験手順

This problem was solved by a method for manufacturing 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, comprising reduction of the product by hydrazine hydrate in presence of a skeletal nickel catalyst, first by interacting 3-nitro-phthalanhydride with hydrazine hydrate in acetic acid at 90-120° C. with formation of 5-nitro-2,3-dihydrophthalazine-1,4-dione, after reduction thereof by hydrazine hydrate in a water-alkaline medium in presence of a skeletal nickel catalyst, isolating 5-amino-2,3-dihydrophthalazine-1,4-dione, which is then treated by sodium hydroxide in the presence of a lower alcohol or a ketone at 20-80° C. to obtain the target product.

出典