反応 #2383804

ord-62e734b3ab7147c69144b4507870d096

反応方程式

Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)OC(C)(C)C)cc4)CC3)cc2)C(=O)OC(C)(C)C)cc1
di-t-butyl ester
Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)OC(C)(C)C)cc4)CC3)cc2)C(=O)OC(C)(C)C)cc1
Piperazine-1,4-dicarboxylic Acid Bis-{4-[(2S)-2-tert-butoxycarbonyl-2-((4R)-5,5-dimethyl-3-(toluene-4-sulfonyl)thiazolidine-4-carboxamido)ethyl]phenyl} Ester
→
Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)O)cc4)CC3)cc2)C(=O)O)cc1
title compound
Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)O)cc4)CC3)cc2)C(=O)O)cc1
Piperazine-1,4-dicarboxylic Acid Bis-{4-[(2S)-2-carboxy-2-((4R)-5,5-dimethyl-3-(toluene-4-sulfonyl)thiazolidine-4carboxamido)ethyl]phenyl} Ester

反応物

Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)OC(C)(C)C)cc4)CC3)cc2)C(=O)OC(C)(C)C)cc1
di-t-butyl ester
Cc1ccc(S(=O)(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H](Cc2ccc(OC(=O)N3CCN(C(=O)Oc4ccc(C[C@H](NC(=O)[C@H]5N(S(=O)(=O)c6ccc(C)cc6)CSC5(C)C)C(=O)OC(C)(C)C)cc4)CC3)cc2)C(=O)OC(C)(C)C)cc1
Piperazine-1,4-dicarboxylic Acid Bis-{4-[(2S)-2-tert-butoxycarbonyl-2-((4R)-5,5-dimethyl-3-(toluene-4-sulfonyl)thiazolidine-4-carboxamido)ethyl]phenyl} Ester

試薬

なし

溶媒

O=CO
formic acid

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他to give a white foam (300 mg, quantitative)

実験手順

The title compound was prepared by hydrolysis of the di-t-butyl ester from Example 299 with formic acid to give a white foam (300 mg, quantitative).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06489300B1uspto-grants-2002_12