反応 #2383798

反応方程式

4-isopropyl-7-nitro-2,3,4,5-tetrahydro-1,4-benzoxazepine

acetic acid

ammonium hydroxide

→

4-Isopropyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-ylamine

溶媒

methanol

water

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate (5×250 ml)
2. 2
   乾燥The extracts were dried with magnesium sulfate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated to an oil (11.34 g, 74%) which

実験手順

To 4-isopropyl-7-nitro-2,3,4,5-tetrahydro-1,4-benzoxazepine (17.46 g) in methanol (1.5 1) was added acetic acid (36 ml) and zinc dust (36 g) portionwise, and the mixture was stirred for 3 h. The mixture was diluted with water (1 1), basified with conc. ammonium hydroxide (250 ml), and extracted with ethyl acetate (5×250 ml). The extracts were dried with magnesium sulfate, filtered and concentrated to an oil (11.34 g, 74%) which was used immediately in the next step.

出典