反応 #2383793

反応方程式

2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

potassium nitrate

→

title compound

収率 22.2%

7-Nitro-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one

収率 22.2%

溶媒

sulfuric acid

反応条件

後処理

1. 1
   workup.WAITfor 4 h at room temperature
2. 2
   ろ過the solids were collected by filtration
3. 3
   温度cooled

実験手順

To 2,3,4,5-tetrahydro-1,4-benzoxazepin-5-one (30.34 g, 190 mmol) in conc. sulfuric acid (600 ml) at 0° C. was added potassium nitrate (20.82 g, 206 mmol) portionwise. The mixture was stirred for 20 minutes at 0° C. and then for 4 h at room temperature. The mixture was poured onto ice (21) and the solids were collected by filtration. The solids were taken up in hot ethyl acetate and then cooled to yield the title compound (8.79 g, 22%), MS m/z 209 [M+H]+.

出典