反応 #2358602

反応方程式

cyclopropyl acetylene

4-iodo 3-fluoro aniline

Et3N

CH2Cl2

→

title compound

収率 50.1%

4-(cyclopropylethynyl)-3-fluoroaniline

収率 50.1%

溶媒

THF

ether

反応条件

後処理

1. 1
   その他The reaction mixture was deoxygenated
2. 2
   その他by purging with a stream of Argon for 30 minutes at −5° C
3. 3
   workup.ADDITIONAddition of Pd(dppf)Cl2
4. 4
   ろ過filtered through celite pad
5. 5
   洗浄washed with ether (2×25 mL)
6. 6
   濃縮The filtrate was concentrated
7. 7
   その他the residue purified by column chromatography (100-200 mesh silica gel)

実験手順

To a stirred solution of 4-iodo 3-fluoro aniline (2.25 g, 9.49 mmol) in THF (25 ml) at 0° C. to −5° C., CuI (90 mg, 0.47 mmol) and Et3N (3.5 ml, 25.62 mmol) were added. The reaction mixture was deoxygenated by purging with a stream of Argon for 30 minutes at −5° C. Addition of Pd(dppf)Cl2.CH2Cl2 (346 mg, 0.47 mmol) and purging was continued. After 10 minutes, cyclopropyl acetylene (0.72 ml, 8.54 mmol) was added at −5° C. and stirred at room temperature for 16 h. The reaction mixture was diluted with ether (200 mL), filtered through celite pad, washed with ether (2×25 mL). The filtrate was concentrated and the residue purified by column chromatography (100-200 mesh silica gel) using hexane as eluent to afford title compound as pale brown liquid (750 mg, 45%).

出典