反応 #2358599

反応方程式

Chlorophenyl acetyl chloride

triethylamine

methanol

→

product

収率 83.4%

Ethyl 2-chloro-2-phenylacetate

収率 83.4%

溶媒

water

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mix
2. 2
   抽出repeatedly extracted with EE (3×100 ml)
3. 3
   乾燥the organic phases were dried over MgSO4
4. 4
   濃縮concentrated under vacuum

実験手順

Chlorophenyl acetyl chloride (53 mmol, 7.6 ml) was added dropwise to a solution of triethylamine (63.5 mmol, 8.7 ml) in methanol at 0° C. and the mixture was subsequently stirred for 3.5 h at room temperature. The reaction mix was then placed in 100 ml of water and repeatedly extracted with EE (3×100 ml). Once combined, the organic phases were dried over MgSO4, concentrated under vacuum and 8.76 g (83.4%) of product was obtained.

出典