反応 #2358579

反応方程式

methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate

iPrOH H2O

→

(S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate

反応条件

後処理

1. 1
   workup.ADDITIONwas added AD-Mix α (1.205 g)
2. 2
   その他then partitioned between 50 mL EtOAc and 25 mL water
3. 3
   その他The organics were separated
4. 4
   乾燥dried over MgSO4
5. 5
   ろ過filtered
6. 6
   濃縮concentrated in vacuo

実験手順

To a suspension of methyl 6-(4-(4-fluorophenoxy)phenyl)-4-vinylpicolinate (0.309 g, 0.884 mmol) in 10 mL 1:1 iPrOH/H2O was added AD-Mix α (1.205 g). The reaction was stirred for 3 h then partitioned between 50 mL EtOAc and 25 mL water. The organics were separated, dried over MgSO4, filtered, and concentrated in vacuo to give crude (S)-methyl 4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)picolinate which was used in the next step without further purification (LC/MS: m/z=384.1 [M+H]+).

出典