反応 #2358576

反応方程式

compound 6

(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(piperazin-1-yl)methanone

3-methylsulfonylbenzenesulfonyl chloride

DIEA

→

compound 8

収率 84.0%

(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)(4-((3-(methylsulfonyl)phenyl)sulfonyl)piperazin-1-yl)methanone

収率 84.0%

溶媒

DCM

反応条件

後処理

1. 1
   その他were reacted

実験手順

According to the methodology described in Example 7, compound 6 (100 mg, 0.24 mmol), 3-methylsulfonylbenzenesulfonyl chloride (60 mg, 0.24 mmol), DIEA (0.1 mL, 0.7 mmol) and DCM (5 mL) were reacted to give compound 8 in 84% yield (LC/MS (m/z+H)=596; 1H NMR (CDCl3) δ ppm: 6.8-8.5 (m, 15H); 4.0 (m, 4H); 3.3 (m, 4H); 3.2 (s, 3H)).

出典