反応 #2358573

反応方程式

Diphenylmethyl bromide

morpholine

triethylamine

→

title compound

収率 14.0%

4-Benzhydrylmorpholine

収率 14.0%

溶媒

chloroform

反応条件

後処理

1. 1
   濃縮the reaction mixture was concentrated in vacuo
2. 2
   その他the resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes)

実験手順

Diphenylmethyl bromide (211 mg, 0.877 mmol) was added to a solution of morpholine (23.9 μL, 0.274 mmol), triethylamine (130 μL, 0.932 mmol) and chloroform (1.4 mL) and was allowed to stir at room temperature. After 48 hr, the reaction mixture was concentrated in vacuo and the resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes) to provide the title compound in 14% yield.

出典